Lessons from SHAKES
lThis does not solve the time problem.
lWhich of these versions is most realistic?
lMutation rate in eukaryotes is 10-8 per replication.
lAll these versions ignore time involved for mutant to take over the population.
lAll the versions suggest a problem for mutating into complex or optimal structures:
lLast pieces of puzzle are highly constrained
lTherefore very unlikely!